HIV/AIDS

GLOSSARY OF TERMS



A

Abstinence

Refers to refraining completely from something; in reference to HIV infection and AIDS, it usually refers to completely avoiding sexual intercourse to avoid passing an HIV infection from one partner to another.

Anemia

The condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood.

AIDS

Acquired immunodeficiency syndrome; this is the result of HIV infection that has seriously injured the immune system and makes the patient subject to fever, chills, night sweats, weight loss, and unusual infections (see "opportunistic infections" below).

Addiction

A problem that is defined by a repeated action that does harm to the person doing it but the person continues to do the activity and usually increases the activity; it can apply to drugs (for example, alcohol, nicotine in cigarettes, pain pills, heroin, cocaine) or to activities (for example, sex, vomiting, eating, and even exercise in extreme cases).

Adherence

Following a plan or treatment program consistently.

Antiretroviral

Any drug or treatment which inhibits or kills a retrovirus like HIV.

Antiviral

Any drug or treatment which inhibits or kills a virus.

Antibiotic

Any drug or treatment which inhibits or kills a microbe or germ; usually this refers to treatments for bacteria (for example, staph or strep).


C

CD4-Lymphocyte

This is the immune cell which is killed by HIV; the number of these cells per unit of blood ("CD4 count") determines how low one's immune system is or how hard one can fight or resist certain infections; this test is not directly affected by treatment (see "Viral Load").

Cervicitis

Refers to an inflammatory condition of the cervix which usually results from a sexually transmitted disease (for example, gonorrhea, chlamydia, herpes).

Cervix

The cuff of tissue that leads into the uterus.

Condom

A device which prevents secretion from one person from touching another person; usually a pouch-like rubber which is fitted over the male penis or into the female vagina; also known as a "rubber."

Complete Blood Count (CBC)

A blood test done to count white cells, red cells, and platelet cells as well as provide information on size of the cells.

Compliance

The preferred term is "Adherence" (see above).

Cryptosporidiosis

Refers to a parasitic infection that causes minor diarrhea in persons with normal immune systems, but in the setting of AIDS, cryptosporidiosis can cause severe, chronic watery diarrhea that can kill.

CT

Refers to "computerized tomography" which is a procedure to use x-rays to make a 3-dimensional picture of the body for diagnosis.

Cytomegalovirus (CMV)

Refers to a virus that very commonly causes minor infections in persons with normal immune systems or less often but more severe infections of the eye, lungs, liver, or brain in persons with AIDS.


D

Dermatitis

Refers to an inflammatory condition of the skin or sometimes to any abnormality of the skin.

Diagnosis

This is the conclusion that a healthcare provider comes to after they review all the available information and tests related to medical problems.

Diarrhea

Loose, liquid and/or frequent stools; diarrhea can be caused by infections (for example food poisoning, antibiotics), drugs (like nelfinavir), poor absorption (for example, too much cream in the diet) or surgery (removal of the colon).


E

ELISA

Enzyme Linked Immuosorbent Assay; this is a screening test that is done for HIV infection as well as for other types of things; in the case of HIV, the ELISA must be confirmed by further testing (see "Western Blot") before the diagnosis of HIV is made.

Encephalitis

Refers to any inflammation within the brain but encephalitis is usually due to infections like syphilis, viruses (for example, West Nile Virus, St Louis encephalitis, herpes), fungus, bacteria or TB.

Erectile Dysfunction (ED)

Refers to problems when the male cannot get or maintain an erection during sexual intercourse; there are many causes including hormones, psychological issues, medications, and nervous system problems.

Esophagitis

Inflammatory condition of the tube (esophagus) that goes from the throat to the stomach, usually due to excess acid (esophageal reflux or GERD) or infection (for example, yeast, herpes, CMV); characterized by usually burning chest pain and pain or difficulty swallowing.


F

Fusion Inhibitor

Refers to a drug that inhibits the binding of HIV to a T-cell (for example, enfuvirtide).


G

Genotype

A blood test to determine what specific resistance a person's strain of HIV has so that medication can be changed for best results.

Gingivitis

Refers to an inflammatory condition of the gums in the mouth that can result in bad breath, tooth decay, and pain; it usually results from not taking care of the mouth and teeth with brushing, flossing, and dental visits; there is an increased risk for gingivitis due to HIV infection.


H

Harm Reduction

Refers to reducing the health impact of unhealthy behaviors such as smoking, alcohol use, nonprescribed drug use, or nonadherence to medications or healthcare visits.

Hemophiliac

A person who lacks factors in the blood that allow it to clot normally; these persons can bleed spontaneously or with minor trauma externally or internally (for example, into joints, into the brain).

Hepatitis

Any condition that is characterized by inflammation of the liver (for example, viral hepatitis, drug hepatitis, alcoholic hepatitis).

Herpes (Simplex) Virus (HSV)

This is a virus which causes cold sores and similar sores on the genital organs or around the anus.

Herpes Zoster (also known as Varicella Zoster)

This is the medical name for shingles which is a outbreak of varicella, the chicken pox virus, that occurs usually along a single nerve producing blisters and pain.

Histoplasmosis

Refers to a fungus infection that causes minor problems if one's immune system is intact, but in the setting of AIDS, it can cause life-threatening infections of the bloodstream, bone marrow, and lungs.

HIV

Human immunodeficiency virus, the virus that causes AIDs; it is also known as HIV-1 and it was formerly known as HTLV III.

Human Papilloma Virus (HPV)

Refers to the virus that causes warts on the body and in the genital areas.


I

Immune System

This refers to the many functions of the human body which resist attack and infections from outside.

Immunodeficiency

This refers to problems with the body's defenses against infections and cancer.

IVDU

Tntravenous drug use or the use of usually illegal drugs injected directly into one's vein.


J

Jaundice

An accumulation of yellow pigment that results in yellow eyes, yellow skin, and usually pale colored stools; this can be caused by hepatitis, breakup of red blood cells, or blocked bile ducts.


K

Kaposi's Sarcoma (KS)

Refers to a malignancy of the blood vessels, lymph nodes, and skin that occurs as result of immunodeficiency like AIDS and the presence of the KS virus (also known as human herpes virus 8, HHV-8); it usually starts on the skin but it may involve almost any organ in the body.


L

Leukoplakia

Refers to any whitish markings in the tissues of the mouth; leukoplakia may be due to viral infections or it might be an early sign of cancer.

Lipids

The fat components of the blood (for example cholesterol, triglycerides, HDL, LDL) which are thought to contribute to risks for heart attacks, strokes, and arterial disease.

Lipoatrophy

This refers to inappropriate loss of fat from certain areas of the body (for example, temples, cheeks, arms, legs) due to HIV and/or certain antiviral medications.

Lipodystrophy

A term used to describe fat redistribution, high fat levels ("lipids") in the blood, and a tendency to cause diabetes that is associated with HIV and certain treatments for HIV.

Liver Enzymes

A blood test that is used to determine the state of the liver's health.

Lymphocytes

These are the lymph cells which are produced by lymph glands to help fight infection.


M

Meninges

Refers to the delicate layers of tissue that surround the brain and spinal cord.

Meningitis

Refers to inflammation in the thin tissues ("meninges") that line the brain and/or spinal cord; usually due to infections with viruses, bacteria, fungi (for example, Cryptococcus neoformans,) or mycobacteria (for example, tuberculosis); meningitis is very serious and can be fatal; symptoms may include headache, fever, light sensitivity to the eyes, stiff neck, nausea, and sometime stroke-like problemsthis refers to a combination of "meningitis" and "encephalitis."

Meningoencephalitis

This refers to a combination of "meningitis" and "encephalitis".

Mitochondria

Refers to tiny structures within human cells which are responsible for the production of energy for the cell; mitochondria may be injured by certain drugs such as NRTIs.

Mononucleosis

This is an acute disease caused by Epstein Barr virus that results in fever, headache, fatigue, and lymph node swelling; sometimes mononucleosis is mimicked by acute infection with HIV or CMV.


N

Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI)

This is a type of drug used against HIV infection that inhibits the production of HIV's genetic material (for example nevirapine, efavirenz, delavirdine).

Nucleoside Reverse Transcriptase Inhibitor (NRTI)

This is a type of drug used against HIV infection that also inhibits the production of HIV's genetic material (for example, zidovudine, didanosine, zalcitabine, stavudine).

Nucleotide Reverse Transcriptase Inhibitor (NtRTI)

This is a slight variation on a NRTI which has undergone an additional chemical reaction ("phosphorylation"); tenofovir is a NtRTI.


O

Opportunistic Infection (OI)

This is an unusual infection that is only possible when one's immune system has been reduced by HIV or other causes (for example, leukemia, cancer chemotherapy); see the page on this site for more details.

Oral Hairy Leukoplakia (OHL)

Refers to whitish markings usually along the sides of the tongue which are due to infection with the mononucleosis virus (Epstein Barr virus, EBV).


P

Pancreas

Refers to an organ in the center of the upper belly which lies just beneath the second part of the stomach; this organ is responsible for secreting digestive juices as well as hormones into the bloodstream; insulin is one of the main hormones secreted by the pancreas' the pancreas can be injured by certain medications (for example, didanosine) as well as by alcohol.

Pancreatitis

Refers to an inflammatory condition of the pancreas that results from many causes (gall stones, drugs, alcohol); the symptoms of pancreatitis are abdominal pain, nausea, vomiting; pancreatitis can be fatal especially if it is acute.

Pelvic Inflammatory Disease (PID)

A complicated infection of the tubes which carry the female eggs to the uterus which produces lower abdominal pain; usually due to sexually transmitted diseases like chlamydia, gonorrhea, and other bacteria.

Peripheral Neuropathy

This refers to the damage that either HIV itself, diabetes, prescribed drugs (for example zalcitabine, stavudine, isoniazid, dapsone,) alcohol and/or other conditions can do to nerves in the feet, legs and even the hands in very severe cases; usually begins as numbness or as if a rock is in one's shoe and gradually increases over days to weeks to months to severe burning pain, sometimes with shock-like or stabbing pain.

Phenotype

A blood test to determine what specific resistance a person's strain of HIV has so that medication can be changed for best results.

Pneumonia

An infection of the airspaces of the lung usually with fever, chills, cough, sputum, chest pain, high white blood cell count, and low oxygen in the blood.

Pneumocystis Pneumonia (PCP)

A special type of possibly life-threatening pneumonia that occurs in AIDS when the immune system is low and the T-cells are usually less than 200.

Prophylaxis

Prevention; this may refer to prevention of sexual transmission or medications used to prevent certain infections.

Protease Inhibitor (PI)

A drug that works against HIV (or other infections) by inhibiting the formation of proteins (for example, saquinavir, indinavir, amprenavir, lopinavir, ritonavir, nelfinavir, atazanavir).


R

Red Blood Cells (RBC)

In the case of HIV therapy this refers to properties of a particular strain of HIV that prevent HIV medication or medications from working; resistance results from nonadherence and/or low blood levels of HIV medications; it does not result usually from stopping HIV medications. Once resistance develops it is usually permanent.

Resistance

In the case of HIV therapy this refers to properties of a particular strain of HIV that prevent HIV medication or medications from working; resistance results from nonadherence and/or low blood levels of HIV medications; it does not result usually from stopping HIV medications. Once resistance develops it is usually permanent.

Retinitis

Refers to an inflammatory state of the light-detecting tissues of the eye ("retina"); usually caused by viruses.


S

Seborrhea

A common and usually minor skin condition that causes redness and scaling between the eyebrows and on the sides of the nose in the folds that lead to the mouth; it can be treated with creams but it will come back if treatment is stopped.

Shingles

See Herpes zoster above.

Spinal Tap

This is the procedure where a healthcare provider places a small needle in the spine to remove fluid for important testing for syphilis, meningitis, or cancer; the procedure is relatively painless and very safe except in very rare instances.

Sputum

The phlegm or material coughed up from the chest or bronchial tubes during a chest cold, bronchitis, pneumonia or tuberculosis.


T

T-cells

This is short for T-helper lymphocytes or CD4-lymphocytes; these cells are the immune system cells that are killed by HIV.

Thrush

Yeast infection of the mouth and/or throat characterized by white cheesy deposits on the gums.

Tinea

A parasite found in cat stools or in undercooked red meat and on unwashed, unpeeled, or uncooked vegetables/frutis that can cause strokes and/or brain damage in someone with AIDS and low T-cells who is not taking a preventative medication.

Toxoplasmosis

A parasite found in cat stools or in undercooked red meat and on unwashed, unpeeled, or uncooked vegetables/frutis that can cause strokes and/or brain damage in someone with AIDS and low T-cells who is not taking a preventative medication.

Tuberculosis (TB)

An infection that is passed back and forth between humans by coughing that is more common in persons with HIV, persons who are alcoholics, persons who have been in jail, and persons born in certain areas of the world (for example, South America, Vietnam, Eastern Europe).

T-cell

This is another name for a CD4-lymphocyte (see above).

Transmission

Refers to the act of passing an infection or a trait to someone else.


V

Vertical Transmission

This refers to mother-to-child infections that occur with HIV and certain other infections and genetic traits.

Viral Load

This is a blood test used to determine how much virus is in the blood either before or during treatment; this test tells how well a treatment is working against HIV.


W

Western Blot

This is a confirmatory blood test for HIV infection that is done to make absolutely sure that a person has HIV.

White Blood Cells (WBC)

These cells are bloodstream cells that are important to the immune system; T-cells are part of the white blood cells.

Wild-Type

HIV that has not mutated and is 100% responsive to antiretro viral medication.